张文华 研究员、硕士生导师

研究方向：焦虑症、抑郁症发病机制及防治

主要荣誉及专业团队任职：江西省“双千计划”科技创新高端人才，金沙集团1862cc首批“三百人才工程”香樟俊才，金沙集团1862cc“215人才工程”赣江青年学者，中国神经科学学会麻醉与脑功能分会青年委员，江西省青年科技协会理事。

邮箱：whzhang@ncu.edu.cn

教育经历：

2008/09 – 2014/06 华中科技大学，生物化学与分子生物学专业，博士

2007/09 – 2008/06 华中科技大学，生物化学与分子生物学专业，硕士

2003 /09– 2007/06 西南大学, 生物科学专业，学士

工作经历：

2021/12 – 至今 金沙集团1862cc，生命科学研究院，研究员

2019/12 – 2021.12 金沙集团1862cc，生命科学研究院，副研究员

2014/07 – 2019/12 金沙集团1862cc，生命科学研究院，助理研究员

奖励和荣誉：

1. 江西省自然科学二等奖（2/4）

2. 江西省“双千计划”科技创新高端人才（青年）

主持课题项目：

1. 国家自然科学基金面上项目，杏仁核神经元紧张性抑制电流差异化变化在应激致过度焦虑中的作用及机制【批准号：31970953；起止时间：2020-2023】；

2. 国家自然科学基金青年基金项目，Rap1在慢性应激致海马神经元结构和突触功能损伤中的作用与机制【批准号：81601179；起止时间：2017-2019】；

3. 江西省“双千计划”科技创新高端人才（青年）项目，基于杏仁核微环路研究抑制性信号在慢性应激引发焦虑障碍的作用【批准号：jxsq2019201095；起止时间：2020-2023】；

4. 江西省自然科学基金重点项目，杏仁核-海马神经环路在慢性应激致过度焦虑中的作用及机制【批准号：20212ACB206038；起止时间：2021-2023】；

5. 江西省自然科学基金杰出青年基金项目，基于前额叶-杏仁核环路研究慢性应激引发焦虑障碍的机制【批准号：20192ACB21024；起止时间：2019-2022】；

6. 江西省自然科学基金面上项目，毒蕈碱型乙酰胆碱M2受体通过网格蛋白非依赖的内吞分子机制研究【批准号：20161BAB204166；起止时间：2016-2017】

7. 江西省自然科学基金青年基金项目，Rap1在慢性应激导致小鼠焦虑样行为的作用及机制研究【批准号：20171BAB214022；起止时间：2017-2019】；

代表性论文（#第一作者，*通讯作者）：

1. Xia Qin, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang*, Bing-Xing Pan*. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67:97-110.

2. Yu Liu#, Ping Hu#, Zhi-Heng Zheng, Da Zhong, Wei-Chang Xie, Zhi-Bo Tang, Bing-Xing Pan*, Jun Luo*, Wen-Hua Zhang*, Xiao-Lei Wang*. Photoresponsive Vaccine-Like CAR-M System with High- Efficiency Central Immune Regulation for Inflammation-related Depression. Advanced Materials, 2021, In press.

3. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan*. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89(9):847-856

4. Zhi-Heng Zheng#, Jiang-Long Tu#, Xiao-Han Li, Qing Hua, Wei-Zhu Liu, Yu Liu, Bing-Xing Pan, Ping Hu, Wen-Hua Zhang*. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behavior and Immunity, 2021, 91:505-518.

5. Shou-He Huang#, Wei-Zhu Liu#, Xia Qin, Chen-Yi Guo, Qing-Cheng Xiong, Yu Wang, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Association of increased amygdala activity with stress-induced anxiety but not social avoidance behavior in mice. Neuroscience Bulletin, 2021, In press.

6. Xia Qin, Xiao-Xuan Liu, Yu Wang, Dan Wang, Ying Song, Jia-Xin Zou, Han-Qing Pan, Xiao-Zhou Zhai, Yong-Mei Zhang, Yang-Bo Zhang, Ping Hu*, Wen-Hua Zhang*. Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala. Life Sciences, 2021, 285:119959.

7. Yun-Yun Wang#, Si-Yu Gai#, Wen-Hua Zhang, Xue-Tao Huang, Shu-Min Ma, Yu-Jia Huo, Yi-Chen Wu, Hai-Jun Tu, Jean-Philippe Pin, Philippe Rondard, Chan-Juan Xu*, Jian-Feng Liu*. The GABAB receptor mediates neuroprotection by coupling to G13. Science Signaling, 2021, 14(705):eaaz4112.

8. Yu-Ge Zhu#, Yun-Xia Lv#, Chen-Yi Guo, Zhi-Min Xiao, Qun-Guang Jiang, Huang Kuang, Wen-Hua Zhang, Ping Hu*. Harmine inhibits the proliferation and migration of glioblastoma cells via FAK/AKT pathway. Life Sciences, 2021, 270:119112.

9. Wen-Jie You#, Ye He#, Wei-Zhu Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang*. Exposure to single prolonged stress fails to induce anxiety-like behavior in mice. Stress and Brain, 2021, 1(1):1-15.

10. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan*. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11:2221.

11. Li-Guo Jin#, Ping Hu#, Yin-Yin Wang, Luo-Jia Wu, Kang Qin, Hao-Xin Cheng, Shu-Hua Wang, Bing-Xing Pan, Hong-Bo Xin, Wen-Hua Zhang*, Xiao-Lei Wang*. Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity. Advanced Materials, 2020, 32(2):e1906050.

12. Wen-Bing Chen#, Han-Qing Pan#, Ye He, Xue-Hui Wang, Wen-Hua Zhang, Bing-Xing Pan*. Rap1b but not Rap1a in the forebrain is required for learned fear. Cell and Bioscience, 2020, 10:107.

13. Han-Qing Pan#, Wen-Hua Zhang#*, Cai-Zhi Liao, Ye He, Zhi-Ming Xiao, Xia-Qin, Wei-Zhu Liu, Na Wang, Jia-Xin Zou, Xiao-Xuan Liu, Bing-Xing Pan*. Chronic stress oppositely regulates tonic inhibition in Thy1-expressing and non-expressing neurons in amygdala. Frontiers in Neuroscience, 2020, 14:299.

14. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan*. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85(10):812-828.

15. Xia Qin, Ye He, Na Wang, Jia-Xin Zou, Yong-Mei Zhang, Jun-Li Cao, Bing-Xing Pan, Wen-Hua Zhang*. Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice. Molecular Brain, 2019, 12:111 .

16. Wen-Hua Zhang#, Ke-Xin Cao#, Zeng-Bo Ding, Jian-Li Yang, Bing-Xing Pan*, Yan-Xue Xue*. Role of prefrontal cortex in the extinction of drug memories. Psychopharmacology, 2019, 236:463-477.

17. Yong-Jian Hu#, Qian Sun#, Wen-Hua Zhang, Yu-Jia Huo, Chan-Juan Xu, Jian-Feng Liu. Specific activation of mGlu2 induced IGF-1R transactivation through FAK phosphorylation. Acta Pharmacologica Sinica, 2019, 40:460-467.

18. Ye He#, Zhi-Heng Zheng#, Jin Zhou, Ping Hu, Bo-Wei Huang, Wei-Zhu Liu, Wen-Jie You, Han-Qing Pan, Bing-Xing Pan, Wen-Hua Zhang*. Gender-dependent regulation of anxiety-like behavior by δ subunit containing GABAA receptor during postnatal development. NeuroReport, 2019, 30:753-759 (Cover paper).

19. Jun-Yu Zhang#, Tao-Hui Liu#, Ye He, Han-Qing Pan, Wen-Hua Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bao-Ming Li, Xiao-Dong Wang, Andrew Holmes, Ti-Fei Yuan, Bing-Xing Pan*. Chronic stress remodels synapses in an amygdala circuit-specific manner. Biological Psychiatry, 2019, 85:189-201.

20. Xiao-Bin Xu*, Shi-Jun Fan, Ruei Tian, Jun-Yu Zhang, Wen-Hua Zhang, Bing-Xing Pan*, Nobumasa Kato. The effects of perinatal bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the prefrontal cortex and hippocampus of rats. Brain and Behavior, 2019, e01225.

21. Wei-Zhu Liu, Bo-Wei Huang, Wen-Jie You, Ping Hu, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Bin Xu, Zong-Yong Zhang, Bing-Xing Pan, Wen-Hua Zhang*. Harmine enhances GABAergic transmission onto basoamygdala projection neurons in mice. Brain Research Bulletin, 2018, 137:294-300.

22. Shi-Yong Wu#, Wen-Hua Zhang#, Shu-Min Ma, Bin Li, Chan-Juan Xu*, Ping Yi*. ERK1/2 and JNK Signaling Synergistically Modulate Mitogenic Effect of Fibroblast Growth Factor 2 on Liver Cell. Cell Biology International, 2018, 42:1511-1522.

23. Jun-Yu Zhang, Xia Qin, Wen-Hua Zhang, Bing-Xing Pan. Role of amygdala in anxiety disorders by chronic stress exposure. Research Signpost Publisher, 2018, Chapter 12: 299~322. (Books)

24. Wen-Hua Zhang, Jin Zhou, Han-Qing Pan, Xiao-Yang Wang, Wei-Zhu Liu, Jun-Yu Zhang, Xiao-Ping Ying, Bing-Xing Pan*. δ subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice. Learning Memory, 2017, 24:381-384.

25. Chen Song#, Wen-Hua Zhang#, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bing-Xing Pan*. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits. Molecular Brain, 2017,10:3.

26. Jing-Jing He#, Wen-Hua Zhang#, Shi-Ling Liu, Yi-Fang Chen, Chen-Xi Liao, Qian-Qing Shen, Ping Hu*. Activation of β2 adrenergic receptor promotes cellular proliferation in human glioblastoma. Oncology Letters, 2017, 14(3):3846-3852.

27. Zhi-Peng Liu#, Qing-Hai He#, Han-Qing Pan, Xiao-Bin Xu, Wen-Bing Chen, Ye He, Jin Zhou, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Ying, Ren-Wen Han, Bao-Ming Li, Tian-Ming Gao, Bing-Xing Pan*. Delta subunit-containing gamma-aminobutyric acid a receptor disinhibits lateral amygdala and facilitates fear expression in mice. Biological Psychiatry, 2017, 81(12):990-1002.

28. Xiao-Bin Xu*, Shi-Jun Fan, Ye He, Xin Ke, Chen Song, Yao Xiao, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Yin, Nobumasa Kato, Bing-Xing Pan*. Loss of hippocampal oligodendrocytes contributes to the deficit of contextual fear learning in adult rats experiencing early bisphenol A exposure. Molecular Neurobiology, 2017, 54(6):4524-4536.

29. Ping Hu#, Wen-Hua Zhang#, Hong-Bo Xin and Glenn Deng*. Single cell isolation and analysis. Frontiers in Cell and Developmental Biology, 2016,4:116.

30. Ping Hu, Jing-Jing He, Shi-Ling Liu, Meng Wang, Bing-Xing Pan, Wen-Hua Zhang*. β2-adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via the ERK1/2/CREB pathway. Oncology Reports, 2016, 36(3):1757-1763.

31. Wen-Hua Zhang#, Chan-Juan Xu#*, Hai-Jun Tu#, Yun-Yun Wang, Qian Sun, Ping Hu, Yong-Jian Hu, Philippe Rondard, Jian-Feng Liu*. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Scientific Reports, 2015, 5:10468.

32. Zong-Yong Zhang#, Wen-Hua Zhang#, Si-Luo Huang#*, Qian Sun, Yun-Yun Wang, Yong-Jian Hu, Ning-Hua Sun, Yi-Lei Zhang, Zhi-Hua Jiang, Li Su*, Jian-Feng Liu*. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. Journal of Cell Science, 2015, 128(12):2302-2313.

33. Min Wan#, Wen-Hua Zhang#, Yang-Li Tian, Chan-Juan Xu, Tao Xu, Jian-Feng Liu*, Rong-Ying Zhang*. Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor. Scientific Reports, 2015, 5:11408.

34. Chan-Juan Xu, Wen-Hua Zhang, Philippe Rondard, Jean Philippe Pin, Jian-Feng Liu*. Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor. Frontiers in Pharmacology. 2014; 5:12.

35. Ping Hu, Bin Li, Wen-Hua Zhang, Yi-Jian Li, Guang Li, Xin-Nong Jiang, Joanna Wdzieczak-Bakala, Jian-Miao Liu*. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. PLoS ONE, 2013, 8(11): e79321.

36. Guillaume A. Baloucoune#, Lei Chun#, Wen-Hua Zhang#, Chan-Juan Xu, Si-Luo Huang, Qian Sun, Yun-Yun Wang, Hai-Jun Tu, Jian-Feng Liu*. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE, 2012, 7(6):e39698.

37. Lei Chun, Wen-Hua Zhang, Jian-Feng Liu*. Structure and ligand recognition of class C GPCRs. Acta Pharmacologica Sinica, 2012, 33:312-323.

38. Xin Lin#, Xin Li#, Ming Jiang#, Lin-Hai Chen#, Chan-Juan Xu, Wen-Hua Zhang, Han zhao, Bing Sun, Xiao-Li Xu, Fa-Jun Nan*, Jian-Feng Liu*. An activity-based probe reveals dynamic protein-protein interactions mediate IGF-1R transactivation by GABAB receptor in neurons. Biochemical Journal, 2012, 443.627-634.

39. Hai-Jun Tu#, Chan-Juan Xu#, Wen-Hua Zhang, Qiu-Yao Liu, Philippe Rondard, Jean-Philippe Pin, Jian-Feng Liu*. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. Journal of Neuroscience. 2010, 30(2):749-59.

40. 邹佳欣，张文华*. 杏仁核神经环路在调控焦虑行为中的作用机制研究进展. 国际麻醉学与复苏杂志，2021，42(10):1108-1113.

41. 贺烨，朱瑜格，刘伟柱，张文华，潘秉兴，胡萍. 肾上腺素能受体在脑胶质瘤发生和发展中作用的研究进展, 生理学报，2020,72(2): 235-242

42. 张文华，孙倩，胡勇箭，刘剑峰. GABAB受体与跨膜受体交叉对话研究新进展.生物物理学报，2013; 29 (10).714-723（封面文章）

43. 张文华，王云云，丁明柳，刘剑峰. GABA受体与脆性X染色体综合征研究新进展.生物物理学报，2013; 29 (11).793-800

44. 蒋明, 黄思罗, 林昕, 春雷, 皮振钧, 孙兵, 张文华, 赵菡, 刘剑峰. GABAB 受体变构剂药学研究进展.现代生物医学进展, 2011; 14.2775-04