段晶晶

金沙集团1862cc(中国)有限公司

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段晶晶 教授、博士生导师

研究方向:鞘脂代谢与衰老

主要荣誉及专业团队任职:国家重大人才计划青年人才项目、江西省双千计划入选者中国老年学和老年医学会学会委员中国营养学会转化医学会委员;人类衰老研究所PI

邮箱:duan.jingjing@ncu.edu.cn

课题组网站:

http://aging.ncu.edu.cn/kytd/49559.htm

https://jingjingduan.wixsite.com/duanlab

教育经历:

2014/08—2017/05 (美)哈佛大学,博士后,导师:David Clapham

2012/06—2014/08 (美)佐治亚理工大学,博士后,导师:Alfred Merrill

2008/09—2012/03 京都大学,博士研究生/博士,导师:平田

2007/09—2008/08 长崎大学研究生,导师:小田 达也

2001/09—2008/07 大连海洋大学,生命科学与技术学院,学士、硕士,导师:李霞

工作经历:

2018/09 金沙集团1862cc 教授

2018/06—2018/08 美国 埃默里大学医学院 Research Fellow

2017/052018/06 美国 霍华德休斯医学研究所 Research Associate

2014/082017/05 美国 哈佛大学/波士顿儿童医院 博士后 Research Fellow

2012/062014/08 美国 佐治亚理工大学 博士后 Research Faculty

执教课程:

本科生课程:生物化学免疫学

研究生课程:生物学前沿进展科技论文写作

主持课题项目

1 国家自然科学基金面上项目鞘脂代谢对离子通道TRPM4/7的功能调控的分子机制研究” 2020.01-2023.12在研

2 国家自然科学基金面上项目新型1-脱氧鞘脂通过干预细胞膜功能及下游S1P信号通路调节衰老的机制”2022.01-2025.12在研

3 国家级人才项目“天然鞘脂与人类健康”在研

4 江西省双千计划项目在研

主要学术贡献及奖励:

2013 “Future Leader in Nutrigenomics”, NUL, NE, USA

2013 Japan Oil Chemists' Society -8th J. Oleo Sci. Impact Award, Japan

2012 “Topics Award” of Japan Society for Bioscience Biotechnology and Agrochemistry

代表性学术论文

Hu Z, Chen Y, Wang X, Deng Y, Wang X, Li S, Ding X, Duan J. Accumulation of Fatty Acylated Fusarium Toxin 2-Amino-14,16-dimethyloctadecan-3-ol, a Class of Novel 1-Deoxysphingolipid Analogues, during Food Storage. J Agric Food Chem. 2022 Apr 27;70(16):5151-5158.通讯作者)

Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022 Feb;298(2):101487. doi: 10.1016/j.jbc.2021.101487. 共同通讯作者

Ding, R. B.; Liu, L.; Hu, Z. Y.; Wu, A. D.; Zhu, H. Y.; Ruan, Q. X.; Qiu, H. M.; Hong, Y. J.; Hu, B. J.; Duan, J. J., In vivo noninvasive and rapid evaluation of pearls in freshwater mussels based on micro-CT. Aquaculture 2021, 534. 通讯作者

Wan, J., Li, J., Bandyopadhyay, S., Kelly, S. L., Xiang, Y., Zhang, J., Merrill, A. H., Jr., Duan, J., Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials. J Agric Food Chem 2019, 67 (46), 12953-12961.(通讯作者)

Duan, J., Li, J., Chen, G. L., Ge, Y., Liu, J., Xie, K., Peng, X., Zhou, W., Zhong, J., Zhang, Y., Xu, J., Xue, C., Liang, B., Zhu, L., Liu, W., Zhang, C., Tian, X. L., Wang, J., Clapham, D. E., Zeng, B., Li, Z., Zhang, J., Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function. Science Advances 2019, 5 (7), eaaw7935.

Duan, J., Li, J., Zeng, B., Chen, G. L., Peng, X. G., Zhang, Y. X., Wang, J. B., Clapham, D. E., Li, Z. L., Zhang, J., Structure of the mouse TRPC4 ion channel. Nature Communications 2018, 9(1):3102.

Duan, J., Li, Z. L., Li, J., Hulse, R. E., Santa-Cruz, A., Valinsky, W. C., Abiria, S. A., Krapivinsky, G., Zhang, J., Clapham, D. E., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. P Natl Acad Sci USA 2018, 115 (35), Eb201-Eb210.

Duan, J., Li, Z. L., Li, J., Santa-Cruz, A., Sanchez-Martinez, S., Zhang, J., Clapham, D. E., Structure of full-length human TRPM4. P Natl Acad Sci USA 2018, 115 (10), 2377-2382.

Duan, J. and Merrill, A.H. 1-Deoxysphingolipids encountered exogenously and made de novo: dangerous mysteries inside an enigma. J Biol Chem 2015 290, 15380-15389.

Duan, J., Ishida, M., Aida, K., Tsuduki, T., Zhang, J., Manabe, Y., Hirata, T. and Sugawara, T. . Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids. J Agric Food Chem 2016 64, 7014–7021. 共同通讯作者